One method I’ve used in a number of imaging tasks is Color Deconvolution. You can think of color deconvolution as figuring out how much of each of a group of colors contributes to the final color of the pixels in an image.
In some ways there are many similarities between Mathematica® and MATLAB®. From the simplest point of view, both are computer mathematics systems. I use both at work and, thus, am a wizard at neither. Let me expose my biases up front though. I like Mathematica enough that I have paid actual money to have a copy at home. With that bias in mind, let’s look at some of the differences.